Diltiazem

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Diltiazem HCl CD Capsules

Hypertens ion: Diltiazem HCl CD produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance. The magnitude of blood pressure reduction is related to the degree of hypertension; thus hypertensive individuals experience an antihypertensive effect, whereas there is only a modest fall in blood pressure in normot...

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Depression associated with diltiazem.

I Selsin BI.. Systemic effects of topical ophthalmic medications. South MedJ7 1983;76:349-58. 2 Hayes LP, Stewart CJ, Kim I, Mohr JA. Timolol side effects and inadvertent overdosing. JAmGeiatr Soc 1989;37:261-2. 3 Pringle SD, MacEwen CJ. Severe bradvcardia due to interaction of timolol eyedrops and verapamil. BrMedJ 1987;294:155-6. 4 Falbe WJ, Boyd DL. Homatropine-associated confusion in an eld...

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Severe dermatitis caused by diltiazem.

A.R. Rodríguez-Orozco , E.G. Kanán-Cedeño, C.E. Barbosa-Sánchez , R.G. Tejeda-Cárdenas , M.E. Vázquez-Romero , A. León-Gutiérrez c a División de Posgrado. Facultad de Medicina «Dr. Ignacio Chávez», Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico b Instituto de Investigación Científica en Temas de Familia, Alergia e Inmunología, Morelia, Mexico c Facultad de Psicología, Univers...

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Characterization of Species Differences in Tissue Diltiazem Deacetylation Identifies Ces2a as a Rat-Specific Diltiazem Deacetylase.

Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyldiltiazem to diltiazem after oral dosing with diltiazem in rats was sevenfold higher than in humans, the molecular mechanisms underlying th...

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Intravenous diltiazem in acute myocardial infarction. Diltiazem as adjunctive therapy to activase (DATA) trial.

OBJECTIVES This study was defined as a pilot investigation of the usefulness and safety of intravenous diltiazem as adjunctive therapy to tissue plasminogen activator in acute myocardial infarction, followed by oral therapy for 4 weeks. BACKGROUND Experimental studies have documented that calcium antagonists protect the myocardial cell against the damage caused by coronary artery occlusion an...

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ژورنال

عنوان ژورنال: Canadian Anaesthetists’ Society Journal

سال: 1985

ISSN: 0008-2856,1496-8975

DOI: 10.1007/bf03008535